The roles of cholecystokinin 2 receptor (CCK2R) in numerous physiologic processes in the gastrointestinal tract and central nervous system are well documented. There has been some evidence that CCK2R alterations play a role in cancers, but the functional significance of these alterations for tumorigenesis is unknown. We have identified six ... More
Measuring molecular rupture forces between single actin filaments and actin-binding proteins.
AuthorsFerrer JM, Lee H, Chen J, Pelz B, Nakamura F, Kamm RD, Lang MJ,
JournalProc Natl Acad Sci U S A
PubMed ID18591676
Actin-binding proteins (ABPs) regulate the assembly of actin filaments (F-actin) into networks and bundles that provide the structural integrity of the cell. Two of these ABPs, filamin and alpha-actinin, have been extensively used to model the mechanical properties of actin networks grown in vitro; however, there is a lack in ... More
Dual roles for an arginine-rich motif in specific genome recognition and localization of viral coat protein to RNA replication sites in flock house virus-infected cells.
AuthorsVenter PA, Marshall D, Schneemann A,
JournalJ Virol
PubMed ID19158251
Assembly of many RNA viruses entails the encapsidation of multiple genome segments into a single virion, and underlying mechanisms for this process are still poorly understood. In the case of the nodavirus Flock House virus (FHV), a bipartite positive-strand RNA genome consisting of RNA1 and RNA2 is copackaged into progeny ... More
Tetraploidy causes chromosomal instability in acentriolar mouse embryos.
Authors
JournalNat Commun
PubMed ID31645568
Rab11 regulates cell-cell communication during collective cell movements.
Authors
JournalNat Cell Biol
PubMed ID23376974
STIM-Orai1 signaling regulates fluidity of cytoplasm during membrane blebbing.
Authors
JournalNat Commun
PubMed ID33473127
Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration.
Authors
JournalNat Commun
PubMed ID31477736
ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma.
Authors
JournalCancer Cell
PubMed ID28669490
CD13 orients the apical-basal polarity axis necessary for lumen formation.
Authors
JournalNat Commun
PubMed ID34349123
Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila.
Authors
JournalNat Commun
PubMed ID32900993
Actin cables and comet tails organize mitochondrial networks in mitosis.
Authors
JournalNature
PubMed ID33658713
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.