Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6.
AuthorsOng YC, Reese ML, Boothroyd JC,
JournalJ Biol Chem
PubMed ID20624917
'The obligate intracellular parasite, Toxoplasma gondii, modulates host immunity in a variety of highly specific ways. Previous work revealed a polymorphic, injected parasite factor, ROP16, to be a key virulence determinant and regulator of host cell transcription. These properties were shown to be partially mediated by dysregulation of the host ... More
Tungsten effects on phosphate-dependent biochemical pathways are species and liver cell line dependent.
AuthorsJohnson DR, Ang C, Bednar AJ, Inouye LS,
JournalToxicol Sci
PubMed ID20421338
Tungsten, in the form of tungstate, polymerizes with phosphate, and as extensive polymerization occurs, cellular phosphorylation and dephosphorylation reactions may be disrupted, resulting in negative effects on cellular functions. A series of studies were conducted to evaluate the effect of tungsten on several phosphate-dependent intracellular functions, including energy cycling (ATP), ... More
Significance of protein tyrosine kinase/protein tyrosine phosphatase balance in the regulation of NF-kappaB signaling in the inflammatory process and aging.
AuthorsJung KJ, Lee EK, Yu BP, Chung HY,
JournalFree Radic Biol Med
PubMed ID19596065
Protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) are well recognized for the essential roles they play in signal transduction by maintaining proper balance under redox status. One of the major transcription factors known to be involved in aging is the redox-sensitive proinflammatory NF-kappaB, which could be modulated by ... More