Cutting edge: tyrosine-independent transmission of inhibitory signals by CTLA-4.
AuthorsCinek T, Sadra A, Imboden JB,
JournalJ Immunol
PubMed ID10604984
CTLA-4 is an important inhibitor of T cell activation. We used Jurkat cells expressing mutants of murine CTLA-4 to study the structural requirements for inhibitory signaling. We find that signals for the inhibition of IL-2 secretion are delivered efficiently by a CTLA-4 mutant in which both cytoplasmic tyrosines have been ... More