Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation.
AuthorsBraun DA, Fribourg M, Sealfon SC,
JournalJ Biol Chem
PubMed ID23166328
'Paradoxically, the pro-inflammatory cytokine IL-6 and the anti-inflammatory cytokine IL-10 both activate STAT3, yet generate nearly opposing cellular responses. Here, we show that the temporal pattern of STAT3 activation codes for the specific cytokine response. A computational model of IL-6 and IL-10 signaling predicted that IL-6 stimulation results in transient ... More