Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease.
AuthorsKarvelis T, Druteika G, Bigelyte G, Budre K, Zedaveinyte R, Silanskas A, Kazlauskas D, Venclovas C, Siksnys V
JournalNature
PubMed ID34619744
'Transposition has a key role in reshaping genomes of all living organisms'
Evaluation of cisplatin-induced injury in human kidney organoids.
AuthorsDigby JLM, Vanichapol T, Przepiorski A, Davidson AJ, Sander V
JournalAm J Physiol Renal Physiol
PubMed ID32150447
Acute kidney injury (AKI) remains a major global healthcare problem, and there is a need to develop human-based models to study AKI in vitro. Toward this goal, we have characterized induced pluripotent stem cell-derived human kidney organoids and their response to cisplatin, a chemotherapeutic drug that induces AKI and preferentially ... More
In situ approaches show the limitation of the spoilage potential of Juniperus phoenicea L. essential oil against cold-tolerant Pseudomonas fluorescens KM24.
AuthorsMyszka K, Tomas N, Wolko L, Szwengiel A, Grygier A, Nuc K, Majcher M
JournalAppl Microbiol Biotechnol
PubMed ID33988734
The present study aimed to elucidate the effect of subinhibitory concentrations (sub-MICs) of juniper essential oil (EO), a-pinene, and sabinene on the quorum-sensing (QS)-mediated proteolytic and lipolytic properties of Pseudomonas fluorescens KM24. These activities were verified under in situ conditions, in which sub-MICs of the agents altered the morphology of ... More
TDP-43 prevents endogenous RNAs from triggering a lethal RIG-I-dependent interferon response.
AuthorsDunker W, Ye X, Zhao Y, Liu L, Richardson A, Karijolich J
JournalCell Rep
PubMed ID33852834
RIG-I-like receptors (RLRs) are involved in the discrimination of self versus non-self via the recognition of double-stranded RNA (dsRNA). Emerging evidence suggests that immunostimulatory dsRNAs are ubiquitously expressed but are disrupted or sequestered by cellular RNA binding proteins (RBPs). TDP-43 is an RBP associated with multiple neurological disorders and is ... More