CTS™ Detachable Dynabeads™ Release Buffer
The Gibco™ CTS™ Detachable Dynabeads™ Release Buffer (SKU A55883) is meant for use only with CTS™ Detachable Dynabeads™ magnetic beads, which may be purchased separately.
CTS™ Detachable Dynabeads™ Release Buffer
Gibco™

CTS™ Detachable Dynabeads™ Release Buffer

The Gibco CTS Detachable Dynabeads Release Buffer is for use with CTS Detachable Dynabeads magnetic beads. When used together, they了解更多信息
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货号数量
A5588302750 mL
A5588303212 mL
A5588301400 mL
货号 A5588302
价格（CNY)
11,052.00
Each
添加至购物车
数量:
750 mL
价格（CNY)
11,052.00
Each
添加至购物车

The Gibco CTS Detachable Dynabeads Release Buffer is for use with CTS Detachable Dynabeads magnetic beads. When used together, they empower users with a first-of-its-kind cGMP cell selection technology that has an active release mechanism for process development, clinical trial, and commercial manufacturing use.

Features of the CTS Detachable Dynabeads Release Buffer (when used with CTS Detachable Dynabeads magnetic beads) include:

  • Empowers users with process flexibility by allowing active release of beads from target cells at any time
  • Optimizes target cell purity, yield, activation profile, and desired phenotype thanks to the active release mechanism that gives users more control
  • Provides an automation-friendly solution by working directly with the CTS DynaCellect Magnetic Separation System
  • Enables consistent performance in light of biological variability within processes
  • Is suitable for both autologous and allogeneic cell therapy manufacturing processes

The CTS Detachable Dynabeads Release Buffer has an active ingredient, biotin, that competitively displaces a biotin derivative on the surface of CTS Detachable Dynabeads magnetic beads. This proprietary mechanism allows users to achieve active release of the beads from target cells at any time within their process. And when used on the CTS DynaCellect Magnetic Separation System, these products deliver automation, flexibility, and scalability in cell therapy manufacturing workflows.

The CTS Detachable Dynabeads Release Buffer also includes Drug Master Files (DMFs) to support cross-referencing in regulatory submissions.

用于研究或生产基于细胞、基因或者组织的产品。注意：不可直接作用于人类或动物给药。
规格
颜色澄清溶液
建议的储存条件Store at 2°C to 8°C and protect from light
最大浓度5 mM
适用于（应用）Cell Therapy
适用于（设备）CTS DynaCellect Magnetic Separation System
分级GMP
物理形态Liquid
数量750 mL
溶液类型Buffer
pH7.0 to 7.4
Unit SizeEach

常见问题解答 (FAQ)

Are CTS Dynabeads and CTS Detachable Dynabeads for clinical trial and commercial manufacturing use?

Yes, CTS Dynabeads and CTS Detachable Dynabeads are GMP-grade and CTS-branded, which means that they are eligible for use in process development, clinical trials, and commercial manufacturing.

Thermo Fisher Scientific’s Cell Therapy Systems (CTS) translates to cGMP manufacturing, testing, and traceability documentation (such as Drug Master Files and Regulatory Support Files) for customer filing needs, and a proven track record of use in many clinical trials and commercialized drugs on the market.

The CTS Dynabeads portfolio, specifically, has been actively used in over 200 clinical trials in 2023 as well as in a number of FDA-approved drugs for commercial use.

Find additional tips, troubleshooting help, and resources within our Dynabeads Cell Isolation and Expansion Support Center.

Can the CTS Detachable Dynabeads Release Buffer be filtered before use?

The CTS Detachable Dynabeads Release Buffer can be filtered with a 0.2 µM PVDF filter before use. Filtration does not negatively affect product performance.

Find additional tips, troubleshooting help, and resources within our Dynabeads Cell Isolation and Expansion Support Center.

Is there a probability that the recombinant human albumin in the CTS Detachable Dynabeads Release Buffer may develop aggregates?

There is a very low probability that the CTS Detachable Dynabeads Release Buffer may develop minor albumin aggregates after agitation. However, internal studies and multiple publications have shown that albumin aggregates do not affect product quality or performance. Please refer to the Certificate of Analysis that contains a similar statement.

If desired, the product can be filtered with a 0.2 µM PVDF filter before use. Filtration does not affect product performance.

Find additional tips, troubleshooting help, and resources within our Dynabeads Cell Isolation and Expansion Support Center.

What are the shipping and storage and conditions for the CTS Detachable Dynabeads Release Buffer?

The CTS Detachable Dynabeads Release Buffer is shipped at 2-8 degrees C. We recommend storing it at 2-8 degrees C, protected from light.

Find additional tips, troubleshooting help, and resources within our Dynabeads Cell Isolation and Expansion Support Center.

What is the shelf-life for the CTS Detachable Dynabeads Release Buffer?

At the time of launch to market for the CTS Detachable Dynabeads Release Buffer in September 2023, the shelf-life was 12 months, but our plan is to extend the shelf-life to 18, 24, 36, 48, and 60 months on a rolling basis. Therefore, our expectation is that the shelf-life will be 5 years by the year 2028.

Find additional tips, troubleshooting help, and resources within our Dynabeads Cell Isolation and Expansion Support Center.

View all CTS™ Detachable Dynabeads™ Release Buffer, 750 mL FAQs