Identification of functional human splenic memory B cells by expression of CD148 and CD27.
AuthorsTangye SG, Liu YJ, Aversa G, Phillips JH, de Vries JE
JournalJ Exp Med
PubMed ID9802981
Memory B cells isolated from human tonsils are characterized by an activated cell surface phenotype, localization to mucosal epithelium, expression of somatically mutated immunoglobulin (Ig) variable (V) region genes, and a preferential differentiation into plasma cells in vitro. In spleens of both humans and rodents, a subset of memory B ... More