Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase.
AuthorsScholefield Z, Yates EA, Wayne G, Amour A, McDowell W, Turnbull JE,
JournalJ Cell Biol
PubMed ID14530380
Cleavage of amyloid precursor protein (APP) by the Alzheimer's beta-secretase (BACE1) is a key step in generating amyloid beta-peptide, the main component of amyloid plaques. Here we report evidence that heparan sulfate (HS) interacts with beta-site APP-cleaving enzyme (BACE) 1 and regulates its cleavage of APP. We show that HS ... More
BACE1 and BACE2 in pathologic and normal human muscle.
BACE1 and BACE2 are recently discovered enzymes participating in processing of amyloid beta precursor protein (AbetaPP). Their discovery is contributing importantly to understanding the mechanism of amyloid-beta generation, and hence the pathogenesis of Alzheimer's disease (AD). Sporadic inclusion-body myositis (s-IBM) and hereditary inclusion-body myopathy (h-IBM) are progressive muscle diseases in ... More