'Proteolytic processing of the amyloid-ß precursor protein (APP) and generation of amyloid-ß peptide (Aß) are key events in Alzheimer''s disease (AD) pathogenesis. Cell biological and genetic evidence has implicated the low-density lipoprotein and sorting receptor LR11/SorLA in AD through mechanisms related to APP and Aß production. Defining the cellular pathway(s) ... More