Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200.
AuthorsShiratori I, Yamaguchi M, Suzukawa M, Yamamoto K, Lanier LL, Saito T, Arase H,
JournalJ Immunol
PubMed ID16177086
'Human and rodent CD200 are recognized by the inhibitory CD200R, and these molecules play an important role in the regulation of the immune system. Several viruses, such as human herpesvirus-6 (HHV-6), HHV-7, and HHV-8, possess a CD200 homologue, suggesting that these viruses regulate the immune response via CD200R. In this ... More
Analysis of the lineage relationship between mast cells and basophils using the c-kit D816V mutation as a biologic signature.
AuthorsKocabas CN, Yavuz AS, Lipsky PE, Metcalfe DD, Akin C,
JournalJ Allergy Clin Immunol
PubMed ID15940128
'Mast cells and basophils share similar morphologic and functional properties; however, it is not known whether they are derived from a bilineage (basophil/mast cell)-restricted progenitor. To assess whether basophils and mast cells are derived from common committed progenitors using the c-kit D816V mutation as a biologic signature. The D816V c-kit ... More