Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin.
AuthorsAagaard-Tillery KM, Jelinek DF,
JournalCell Immunol
PubMed ID7517796
'In this study, we have analyzed the effects of the immunosuppressive agent rapamycin on the activation of highly purified normal human B lymphocytes. When the polyclonal activators Staphylococcus aureus (SA) and soluble CD40 ligand (CD40L) were used to stimulate B cells, rapamycin inhibited both interleukin 2 (IL2)-dependent and -independent proliferation, ... More