The immunoglobulin (IgG) antibody response to OspA and OspB correlates with severe and prolonged Lyme arthritis and the IgG response to P35 correlates with mild and brief arthritis.
AuthorsAkin E, McHugh GL, Flavell RA, Fikrig E, Steere AC,
JournalInfect Immun
PubMed ID9864212
In an effort to implicate immune responses to specific Borrelia burgdorferi proteins that may have a role in chronic Lyme arthritis, we studied the natural history of the antibody response to B. burgdorferi in serial serum samples from 25 patients monitored throughout the course of Lyme disease. In these patients, ... More
Cellular and humoral immune responses to Borrelia burgdorferi antigens in patients with culture-positive early Lyme disease.
AuthorsVaz A, Glickstein L, Field JA, McHugh G, Sikand VK, Damle N, Steere AC,
JournalInfect Immun
PubMed ID11705918
We determined cellular and humoral immune responses to Borrelia burgdorferi lysate and to recombinant flagellin (FlaB), OspC, and OspA in acute- and convalescent-phase samples from 39 culture-positive patients with erythema migrans and in 20 healthy control subjects. During the acute illness, a median of 4 days after the onset of ... More