Blockage of CXCR2 suppresses tumor growth of intrahepatic cholangiocellular carcinoma.
AuthorsSueoka H, Hirano T, Uda Y, Iimuro Y, Yamanaka J, Fujimoto J,
Journal
PubMed ID24582495
'Complete operative resection is the only approach to cure for intrahepatic cholangiocellular carcinoma (ICC), but the disease''s prognosis is notably poor. A novel therapeutic approach is urgently required. CXC chemokine receptor 2 (CXCR2) has been associated with tumorigenesis and metastasis in human cancers. In this study, we investigated the suppressive ... More
Dynamic regulation of CXCR1 and CXCR2 homo- and heterodimers.
AuthorsMartínez Muñoz L, Lucas P, Navarro G, Checa AI, Franco R, Martínez-A C, Rodríguez-Frade JM, Mellado M,
JournalJ Immunol
PubMed ID19890050
Although homo- and heterodimerization are reported for some chemokine receptors, it remains unclear whether these functional states are in dynamic equilibrium and how receptor/ligand levels influence oligomerization. In human neutrophils and in cell lines that coexpress the chemokine receptors CXCR1 and CXCR2, we used fluorescence resonance energy transfer techniques to ... More