RNAlater Stabilization Solution and RNAlater-ICE Frozen Transition Solution are known to react with hypochlorite solutions, such as common bleach. The reaction releases chlorine gas and generates heat. A similar reaction may occur with other oxidizing agents. If you suspect that samples may contain bleach or other oxidizing reagents, we recommend working in a fume hood with adequate protective clothing and equipment.
Find additional tips, troubleshooting help, and resources within our RNA Sample Collection, Protection, and Isolation Support Center.