Multiparameter analysis of progeny of individual cells by laser scanning cytometry.
AuthorsBedner E, Ruan Q, Chen S, Kamentsky LA, Darzynkiewicz Z
JournalCytometry
PubMed ID10918278
BACKGROUND: Effectiveness of antitumor drugs to suppress unrestricted proliferation of cancer cells is commonly measured by cell clonogenicity assays. Assays of clonogenicity are also used in studies of stem/progenitor cells and in analysis of carcinogenic transformation. The conventional assays are limited to providing information about frequency of colonies (cloning efficiency) ... More