Multiple fluorescent ligands for dopamine receptors. II. Visualization in neural tissues.
AuthorsAriano MA, Kang HC, Haugland RP, Sibley DR
JournalBrain Res
PubMed ID1884196
'Selective dopamine receptor ligands, (R,S)-5-(4'-aminophenyl)-8-chloro-2,3,4, 5-tetrahydro-3-methyl-[1H]-3-benzazepin-7-ol, the 4'-amino derivative of the high affinity D1 receptor antagonist SCH 23390, the high affinity D2 receptor antagonist N-(p-aminophenethyl)-spiperone or NAPS, and the D2 selective agonist, 2-(N-phenethyl-N-propyl)-amino-5-hydroxytetralin or PPHT were chemically coupled to the fluorescent compounds, Bodipy, Cascade blue, coumarin, fluorescein, rhodamine, or Texas ... More
Multiple fluorescent ligands for dopamine receptors. I. Pharmacological characterization and receptor selectivity.
AuthorsBarton AC, Kang HC, Rinaudo MS, Monsma FJ, Stewart-Fram RM, Macinko JA, Haugland RP, Ariano MA, Sibley DR
JournalBrain Res
PubMed ID1679366
We report the synthesis and pharmacological characterization of novel fluorescently labeled ligands with high affinity and specificity for D1 and D2 dopamine receptors. D1-selective antagonist probes have been synthesized using (R,S)-5-(4'-aminophenyl)-8-chloro-2,3,4,5-tetrahydro-3-methyl-[1H]-3- benzazepin-7-ol, the 4'-amino derivative of the high affinity D1-selective antagonist, SCH-23390, while D2-selective antagonist probes were synthesized using the ... More