'The spectroscopic properties of a new series of fatty acid analogs in which a dipyrrometheneboron difluoride fluorophore forms a segment of the acyl methylene chain are presented and their characteristics as fluorescent membrane probes are examined. When incorporated as a low mole fraction component in model phospholipid membranes, the probes ... More
The antimicrobial peptide trichogin and its interaction with phospholipid membranes.
AuthorsEpand RF, Epand RM, Monaco V, Stoia S, Formaggio F, Crisma M, Toniolo C
JournalEur J Biochem
PubMed ID10583397
'The interaction of the antimicrobial peptide trichogin GA IV with phospholipid bilayers has been studied. A series of analogs of trichogin was synthesized in which the nitroxide spin label, 4-amino-4-carboxy-2,2,6,6-tetramethylpiperidino-1-oxyl (TOAC), replaced one of the three alpha-aminoisobutyric acid (Aib) residues in the sequence. These modified peptides were used to assess ... More
Purification and analysis of a phospholipase A2-like lytic factor of Trichomonas vaginalis.
AuthorsLubick KJ, Burgess DE
JournalInfect Immun
PubMed ID14977929
Trichomonas vaginalis produces soluble factors that have been reported to have the ability to damage target cells in vitro, and it has been hypothesized that these factors may play a role in the pathogenesis of human trichomoniasis. A lytic factor (LF) was purified from T. vaginalis, and the molecular characteristics ... More