Soluble amyloid-beta buffering by plaques in Alzheimer disease dementia versus high-pathology controls.
AuthorsEsparza TJ, Gangolli M, Cairns NJ, Brody DL,
JournalPLoS One
PubMed ID29979775
An unanswered question regarding Alzheimer disease dementia (ADD) is whether amyloid-beta (Aß) plaques sequester toxic soluble Aß species early during pathological progression. We previously reported that the concentration of soluble Aß aggregates from patients with mild dementia was higher than soluble Aß aggregates from patients with modest Aß plaque burden ... More