Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathway.
AuthorsDeshors P, Toulas C, Arnauduc F, Malric L, Siegfried A, Nicaise Y, Lemarié A, Larrieu D, Tosolini M, Cohen-Jonathan Moyal E, Courtade-Saidi M, Evrard SM
JournalCell Death Dis
PubMed ID31659157
'Glioblastomas (GBM) are brain tumors with a poor prognosis despite treatment that combines surgical resection and radio-chemotherapy. These tumors are characterized by abundant vascularization and significant cellular heterogeneity including GBM stem-like cells (GSC) which contribute to tumor aggressiveness, resistance, and recurrence. Recent data has demonstrated that GSC are directly involved ... More
Optimization of prostate cancer cell detection using multiplex tyramide signal amplification.
Approximately 29?000 men die of prostate cancer (PCa) each year in the United States, and 90% to 100% of them are due to incurable bone metastasis. It is difficult to determine (1) when PCa disseminates in the natural history of the disease; (2) where cancer cell disseminates before becoming overt ... More