The intraacrosomal calcium pool plays a direct role in acrosomal exocytosis.
AuthorsDe Blas G, Michaut M, Treviño CL, Tomes CN, Yunes R, Darszon A, Mayorga LS
JournalJ Biol Chem
PubMed ID12379648
The acrosome reaction is a unique type of regulated exocytosis. The single secretory granule of the sperm fuses at multiple points with the overlying plasma membrane. In the past few years we have characterized several aspects of this process using streptolysin O-permeabilized human spermatozoa. Here we show that Rab3A triggers ... More