Involvement of Exo1b in DNA damage-induced apoptosis.
AuthorsBolderson E, Richard DJ, Edelmann W, Khanna KK,
JournalNucleic Acids Res
PubMed ID19339515
'Apoptosis is essential for the maintenance of inherited genomic integrity. During DNA damage-induced apoptosis, mechanisms of cell survival, such as DNA repair are inactivated to allow cell death to proceed. Here, we describe a role for the mammalian DNA repair enzyme Exonuclease 1 (Exo1) in DNA damage-induced apoptosis. Depletion of ... More
HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression.
AuthorsCheshenko N, Trepanier JB, Stefanidou M, Buckley N, Gonzalez P, Jacobs W, Herold BC,
JournalFASEB J
PubMed ID23507869
HSV triggers intracellular calcium release to promote viral entry. We hypothesized that Akt signaling induces the calcium responses and contributes to HSV entry. Exposure of human cervical and primary genital tract epithelial, neuronal, or keratinocyte cells to HSV serotype 2 resulted in rapid phosphorylation of Akt. Silencing of Akt with ... More
Pharmacological inhibition of mitochondrial carbonic anhydrases protects mouse cerebral pericytes from high glucose-induced oxidative stress and apoptosis.
AuthorsShah GN, Price TO, Banks WA, Morofuji Y, Kovac A, Ercal N, Sorenson CM, Shin ES, Sheibani N,
JournalJ Pharmacol Exp Ther
PubMed ID23249625
Diabetes-associated complications in the microvasculature of the brain are caused by oxidative stress, generated by overproduction of reactive oxygen species from hyperglycemia-induced accelerated oxidative metabolism of glucose. Pericytes, essential for the viability of the microvasculature, are especially susceptible to oxidative stress. Mitochondrial carbonic anhydrases, regulators of the oxidative metabolism of ... More
Dual suppression of hemangiogenesis and lymphangiogenesis by splice-shifting morpholinos targeting vascular endothelial growth factor receptor 2 (KDR).
AuthorsUehara H, Cho Y, Simonis J, Cahoon J, Archer B, Luo L, Das SK, Singh N, Ambati J, Ambati BK,
JournalFASEB J
PubMed ID22997228
The KDR gene, which participates in angiogenesis and lymphangiogenesis, produces two functionally distinct protein products, membrane-bound KDR (mbKDR) and its isoform, soluble KDR (sKDR). Since sKDR does not have a tyrosine kinase domain and does not dimerize, it is principally an antagonist of lymphangiogenesis by sequestering VEGF-C. Alternative polyadenylation of ... More
Mitochondrial Akt-regulated mitochondrial apoptosis signaling in cardiac muscle cells.
AuthorsSu CC, Yang JY, Leu HB, Chen Y, Wang PH,
JournalAm J Physiol Heart Circ Physiol
PubMed ID22081709
We recently reported translocation and activation of Akt in cardiac mitochondria. This study was to determine whether activation of Akt in mitochondria could inhibit apoptosis of cardiac muscle cells. Insulin stimulation induced translocation of phosphorylated Akt to the mitochondria in primary cardiomyocytes. A mitochondria-targeted constitutively active Akt was overexpressed via ... More
Phosphatidylserine is a critical modulator for Akt activation.
AuthorsHuang BX, Akbar M, Kevala K, Kim HY,
JournalJ Cell Biol
PubMed ID21402788
Akt activation relies on the binding of Akt to phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) in the membrane. Here, we demonstrate that Akt activation requires not only PIP(3) but also membrane phosphatidylserine (PS). The extent of insulin-like growth factor-induced Akt activation and downstream signaling as well as cell survival under serum starvation conditions positively ... More
Vasopressin inhibits apoptosis in renal collecting duct cells.
The peptide hormone arginine vasopressin (AVP) plays a critical role in regulating salt and water transport in the mammalian kidney. Recent studies have also demonstrated that AVP can promote cell survival in neuronal cells through V1 receptors. The current study addresses whether AVP can inhibit apoptosis in kidney collecting duct ... More
Cyp1b1-deficient retinal astrocytes are more proliferative and migratory and are protected from oxidative stress and inflammation.
AuthorsFalero-Perez J, Sorenson CM, Sheibani N
JournalAm J Physiol Cell Physiol
PubMed ID30892936
'Astrocytes (ACs) are the most abundant cells in the central nervous system. Retinal ACs play an important role in maintaining the integrity of retinal neurovascular function, and their dysfunction contributes to the pathogenesis of various eye diseases including diabetic retinopathy. Cytochrome P450 1B1 (CYP1B1) expression in the neurovascular structures of ... More
Microglia-induced IL-6 protects against neuronal loss following HSV-1 infection of neural progenitor cells.
Authors
JournalGlia
PubMed ID24807365
Bim expression modulates the pro-inflammatory phenotype of retinal astroglial cells.
AuthorsFalero-Perez J, Sheibani N, Sorenson CM
JournalPLoS One
PubMed ID32365083
'Apoptosis of neurovascular cells, including astroglial cells, contributes to the pathogenesis of diseases in which neurovascular disruption plays a central role. Bim is a pro-apoptotic protein that modulates not only apoptosis but also various cellular functions such as migration and extracellular matrix protein expression. Astroglial cells act as an intermediary ... More
Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells.
Authors
JournalDev Cell
PubMed ID27499523
Targeted intraceptor nanoparticle therapy reduces angiogenesis and fibrosis in primate and murine macular degeneration.
Authors
JournalACS Nano
PubMed ID23464925
Mechano-signaling via Piezo1 prevents activation and p53-mediated senescence of muscle stem cells.
Authors
JournalRedox Biol
PubMed ID35395625
IFNB1/interferon-β-induced autophagy in MCF-7 breast cancer cells counteracts its proapoptotic function.
Authors
JournalAutophagy
PubMed ID23221969
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.
Authors
JournalNat Med
PubMed ID30510257
Ferrochelatase is a therapeutic target for ocular neovascularization.
Authors
JournalEMBO Mol Med
PubMed ID28377496
Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration.
Authors
JournalMol Neurodegener
PubMed ID29439717
Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation.
Authors
JournalNat Commun
PubMed ID30504773
AAV2 delivery of Flt23k intraceptors inhibits murine choroidal neovascularization.
Authors
JournalMol Ther
PubMed ID25306972
Local convection-enhanced delivery of an anti-CD40 agonistic monoclonal antibody induces antitumor effects in mouse glioma models.
AuthorsShoji T, Saito R, Chonan M, Shibahara I, Sato A, Kanamori M, Sonoda Y, Kondo T, Ishii N, Tominaga T
JournalNeuro Oncol
PubMed ID26917236
Glioblastoma is one of the most malignant brain tumors in adults and has a dismal prognosis. In a previous report, we reported that CD40, a TNF-R-related cell surface receptor, and its ligand CD40L were associated with glioma outcomes. Here we attempted to activate CD40 signaling in the tumor and determine ... More
Regulatory role of NADPH oxidase 2 in the polarization dynamics and neurotoxicity of microglia/macrophages after traumatic brain injury.
AuthorsWang J, Ma MW, Dhandapani KM, Brann DW
JournalFree Radic Biol Med
PubMed ID28942245
Traumatic brain injury (TBI) is a leading cause of death and disability. Secondary injuries that develop after the initial trauma contribute to long-lasting neurophysiological deficits. Polarization of microglia/macrophages toward a pro-inflammatory (M1) phenotype may increase the progression of secondary injury following TBI; however, the regulatory and functional mechanisms underlying these ... More
Ion channel signaling influences cellular proliferation and phagocyte activity during axolotl tail regeneration.
AuthorsFranklin BM, Voss SR, Osborn JL
JournalMech Dev
PubMed ID28603004
Little is known about the potential for ion channels to regulate cellular behaviors during tissue regeneration. Here, we utilized an amphibian tail regeneration assay coupled with a chemical genetic screen to identify ion channel antagonists that altered critical cellular processes during regeneration. Inhibition of multiple ion channels either partially (anoctamin1/Tmem16a, ... More
Establishment of a method for evaluating endothelial cell injury by TNF-a in vitro for clarifying the pathophysiology of virus-associated acute encephalopathy.
AuthorsMiyazaki K, Hashimoto K, Sato M, Watanabe M, Tomikawa N, Kanno S, Kawasaki Y, Momoi N, Hosoya M
JournalPediatr Res
PubMed ID28157839
Virus-associated acute encephalopathy (VAE) is a severe central nervous system complication caused by common viral infections in children. The pathophysiology of VAE is thought to be endothelial injury. This study was designed to establish an in vitro VAE model for evaluating endothelial injury caused by the proinflammatory cytokine TNF-a. ... More
Deletion of NADPH oxidase 4 reduces severity of traumatic brain injury.
AuthorsMa MW, Wang J, Dhandapani KM, Brann DW
JournalFree Radic Biol Med
PubMed ID29391196
Traumatic brain injury (TBI) contributes to over 30% of injury-related deaths and is a major cause of disability without effective clinical therapies. Oxidative stress contributes to neurodegeneration, neuroinflammation, and neuronal death to amplify the primary injury after TBI. NADPH oxidase (NOX) is a major source of reactive oxygen species following ... More
Prolonged elevated levels of c-kit+ progenitor cells after a myocardial infarction by beta 2 adrenergic receptor priming.
AuthorsFinan A, Demion M, Sicard P, Guisiano M, Bideaux P, Monceaux K, Thireau J, Richard S
JournalJ Cell Physiol
PubMed ID30912139
Endogenous progenitor cells may participate in cardiac repair after a myocardial infarction (MI). The beta 2 adrenergic receptor (ß2-AR) pathway induces proliferation of c-kit+ cardiac progenitor cells (CPC) in vitro. We investigated if ß2-AR pharmacological stimulation could ameliorate endogenous CPC-mediated regeneration after a MI. C-kit+ CPC ß1-AR and ß2-AR expression ... More
1,25(OH)
AuthorsJamali N, Song YS, Sorenson CM, Sheibani N
JournalFASEB Bioadv
PubMed ID31396585
We have previously demonstrated that the active form of vitamin D (calcitriol; 1,25(OH)
PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytes.
AuthorsJeong MH, Jeong HJ, Ahn BY, Pyun JH, Kwon I, Cho H, Kang JS
JournalCell Death Dis
PubMed ID31787756
Endoplasmic reticulum (ER) stress signaling plays a critical role in the control of cell survival or death. Persistent ER stress activates proapoptotic pathway involving the ATF4/CHOP axis. Although accumulating evidences support its important contribution to cardiovascular diseases, but its mechanism is not well characterized. Here, we demonstrate a critical role ... More