MicroRNA-27 (miR-27) Targets Prohibitin and Impairs Adipocyte Differentiation and Mitochondrial Function in Human Adipose-derived Stem Cells.
AuthorsKang T, Lu W, Xu W, Anderson L, Bacanamwo M, Thompson W, Chen YE, Liu D,
Journal
PubMed ID24133204
Prohibitin (PHB) has been reported to play a crucial role in adipocyte differentiation and mitochondrial function. However, the regulative mechanism of PHB during adipogenesis remains unclear. In this study, we determined that the levels of both microRNA (miR)-27a and miR-27b were down-regulated following adipogenic induction of human adipose-derived stem cells, ... More
Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise-Induced High-Turnover Metabolism.
Authors
JournalCell Metab
PubMed ID33535098
Anti-inflammatory effect of strawberry extract against LPS-induced stress in RAW 264.7 macrophages.
AuthorsGasparrini M, Forbes-Hernandez TY, Giampieri F, Afrin S, Alvarez-Suarez JM, Mazzoni L, Mezzetti B, Quiles JL, Battino M
JournalFood Chem Toxicol
PubMed ID28130090
'A common denominator in the pathogenesis of most chronic inflammatory diseases is the involvement of oxidative stress, related to ROS production by all aerobic organisms. Dietary antioxidants from plant foods represent an efficient strategy to counteract this condition. The aim of the present study was to evaluate the protective effects ... More
Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling.
Authors
JournalCell Metab
PubMed ID29972798
Integrative Omics Analyses Reveal Epigenetic Memory in Diabetic Renal Cells Regulating Genes Associated With Kidney Dysfunction.
Authors
JournalDiabetes
PubMed ID32747424
Epidermal Growth Factor (EGF) Augments the Invasive Potential of Human Glioblastoma Multiforme Cells via the Activation of Collaborative EGFR/ROS-Dependent Signaling.
Autophagy in osteoblasts is involved in mineralization and bone homeostasis.
Authors
JournalAutophagy
PubMed ID25484092
A requirement for PAK1 to support mitochondrial function and maintain cellular redox balance via electron transport chain proteins to prevent β-cell apoptosis.
Authors
JournalMetabolism
PubMed ID33181191
A Positive Feed Forward Loop between Wnt/β-Catenin and NOX4 Promotes Silicon Dioxide-Induced Epithelial-Mesenchymal Transition of Lung Epithelial Cells.
Authors
JournalOxid Med Cell Longev
PubMed ID33376577
Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance.
Authors
JournalCell Metab
PubMed ID32763164
Multicolor two-photon imaging of in vivo cellular pathophysiology upon influenza virus infection using the two-photon IMPRESS.
Authors
JournalNat Protoc
PubMed ID31996843
Reactive oxygen species mediate insulin signal transduction in mouse hypothalamus.
AuthorsOnoue T, Goto M, Tominaga T, Sugiyama M, Tsunekawa T, Hagiwara D, Banno R, Suga H, Sugimura Y, Arima H
JournalNeurosci Lett
PubMed ID26968348
In the hypothalamus, several reports have implied that ROS mediate physiological effects of insulin. In this study, we investigated the mechanisms of insulin-induced ROS production and the effect of ROS on insulin signal transduction in mouse hypothalamic organotypic cultures. Insulin increased intracellular ROS, which were suppressed by NADPH oxidase inhibitor. ... More
Oxidative stress serves as a key checkpoint for IL-33 release by airway epithelium.
AuthorsUchida M, Anderson EL, Squillace DL, Patil N, Maniak PJ, Iijima K, Kita H, O'Grady SM
JournalAllergy
PubMed ID28273344
Interleukin (IL)-33 is implicated in the pathophysiology of asthma and allergic diseases. However, our knowledge is limited regarding how IL-33 release is controlled. The transcription factor nuclear factor-erythroid-2-related factor 2 (Nrf2) plays a key role in antioxidant response regulation. ... More
Salidroside prevents hydroperoxide-induced oxidative stress and apoptosis in retinal pigment epithelium cells.
AuthorsYin Y, Liu D, Tian D
JournalExp Ther Med
PubMed ID30210588
Salidroside (SAL) is the major pharmacologically active constituent of
Modulation of Antioxidant Potential with Coenzyme Q10 Suppressed Invasion of Temozolomide-Resistant Rat Glioma
AuthorsBuric SS, Podolski-Renic A, Dinic J, Stankovic T, Jovanovic M, Hadžic S, Ayuso JM, Virumbrales-Muñoz M, Fernández LJ, Ochoa I, Pérez-García VM, Pešic M
JournalOxid Med Cell Longev
PubMed ID30984333
The main reasons for the inefficiency of standard glioblastoma (GBM) therapy are the occurrence of chemoresistance and the invasion of GBM cells into surrounding brain tissues. New therapeutic approaches obstructing these processes may provide substantial survival improvements. The purpose of this study was to assess the potential of lipophilic antioxidant ... More
Anti-inflammatory and immune-modulating effects of rice callus suspension culture (RCSC) and bioactive fractions in an in vitro inflammatory bowel disease model.
AuthorsDriscoll K, Deshpande A, Chapp A, Li K, Datta R, Ramakrishna W
JournalPhytomedicine
PubMed ID30831485
Rice callus suspension culture (RCSC) has been shown to exhibit potent antiproliferative activity in multiple cancer cell lines. RCSC and its bioactive compounds can fill the need for drugs with no side effects. ... More
Anti-inflammatory Effects of Northern Highbush Blueberry Extract on an
AuthorsDriscoll K, Deshpande A, Datta R, Ramakrishna W
JournalNutr Cancer
PubMed ID31588794
Blueberry anthocyanins have the ability to efficiently reach the GI tract and exhibit a broad range of biochemical effects. In the context of inflammatory bowel disease (IBD), they remain a promising complement to current IBD treatments. Here, we investigated the anti-inflammatory and antioxidant capabilities of Highbush blueberries ... More