Signaling and physiological activity of the NO-donating agent TNICthio in human blood lymphocytes, Jurkat and MCF7 cell lines.
AuthorsVasilieva SV, Petrishcheva MS, Yashkina EI, Osipov AN
JournalMol Biol Rep
PubMed ID30637625
'Signaling and physiological activities of the crystalline tetranitrosyl iron complex with thiosulfate-a NO-donor (TNICthio) were first studied on human cells in conditions of mono and combined application of H' ... More
Characterization of NvLWamide-like neurons reveals stereotypy in Nematostella nerve net development.
The organization of cnidarian nerve nets is traditionally described as diffuse with randomly arranged neurites that show minimal reproducibility between animals. However, most observations of nerve nets are conducted using cross-reactive antibodies that broadly label neurons, which potentially masks stereotyped patterns produced by individual neuronal subtypes. Additionally, many cnidarians species ... More
The Antidiabetic Drug Lobeglitazone Protects Mice From Lipogenesis-Induced Liver Injury via Mechanistic Target of Rapamycin Complex 1 Inhibition.
AuthorsLee YS, Park JS, Lee DH, Lee DK, Kwon SW, Lee BW, Bae SH
JournalFront Endocrinol (Lausanne)
PubMed ID30298052
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder closely linked with type II diabetes (T2D). The progression of NAFLD is associated with the induction of lipogenesis through hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) pathway. An increase in lipogenesis induces endoplasmic reticulum (ER) stress and accelerates ... More
Inhibition of WNT7A-ß-catenin signaling pathway sensitizes oral squamous cell carcinoma to cisplatin.
AuthorsTian J, Cui X, Feng Y, Gu L
JournalInt J Clin Exp Pathol
PubMed ID31949568
Oral squamous cell carcinoma (OSCC) is the most common type and most threatening head and neck cancer worldwide. Here, we aim to study the relationship between the WNT7A-ß-Catenin signaling pathway and the chemotherapy resistance of OSCC patients. We analyzed 42 OSCC patients and 19 adjacent non-tumor tissues, evaluated the expression ... More
Small Molecule GSK-J1 Affects Differentiation of Specific Neuronal Subtypes in Developing Rat Retina.
AuthorsRaeisossadati R, Móvio MI, Walter LT, Takada SH, Del Debbio CB, Kihara AH
JournalMol Neurobiol
PubMed ID29981055
Histone post-translational modification has been shown to play a pivotal role in regulating gene expression and fate determination during the development of the central nervous system. Application of pharmacological blockers that control histone methylation status has been considered a promising avenue to control abnormal developmental processes and diseases as well. ... More
Influence of Fat on Differential Receptor Interacting Serine/Threonine Protein Kinase 1 Activity Leading to Apoptotic Cell Death in Murine Liver Ischemia Reperfusion Injury Through Caspase 8.
AuthorsKolachala VL, Palle SK, Shen M, Shenoi A, Shayakhmetov DM, Gupta NA
JournalHepatol Commun
PubMed ID31334443
Current understanding is that receptor interacting serine/threonine protein kinase 1 (RIPK1) can lead to two distinct forms of cell death: RIPK3-mediated necroptosis or caspase 8 (Casp8)-mediated apoptosis. Here, we report that RIPK1 signaling is indispensable for protection from hepatocellular injury in a steatotic liver undergoing ischemia reperfusion injury (IRI) but ... More
Role of Translational Attenuation in Inherited Retinal Degeneration.
AuthorsStarr CR, Nyankerh CNA, Qi X, Hu Y, Gorbatyuk OS, Sonenberg N, Boulton ME, Gorbatyuk MS
JournalInvest Ophthalmol Vis Sci
PubMed ID31747684
We reported previously that retinas of mice with inherited retinal degeneration make less protein than retinas of normal mice. Despite recent studies suggesting that diminished protein synthesis rates may contribute to neurologic disorders, a direct link between protein synthesis rates and the progression of neurodegeneration has not been established. Moreover, ... More
eIF2a-CHOP-BCl-2/JNK and IRE1a-XBP1/JNK signaling promote apoptosis and inflammation and support the proliferation of Newcastle disease virus.
AuthorsLi Y, Jiang W, Niu Q, Sun Y, Meng C, Tan L, Song C, Qiu X, Liao Y, Ding C
JournalCell Death Dis
PubMed ID31767828
Newcastle disease virus (NDV) causes severe infectious disease in poultry and selectively kills tumor cells, by inducing apoptosis and cytokines secretion. In this report, we study the mechanisms underlying NDV-induced apoptosis by investigating the unfolded protein response (UPR). We found that NDV infection activated all three branches of the UPR ... More
Apelin protects auditory cells from cisplatin-induced toxicity in vitro by inhibiting ROS and apoptosis.
AuthorsYin H, Zhang H, Kong Y, Wang C, Guo Y, Gao Y, Yuan L, Yang X, Chen J
JournalNeurosci Lett
PubMed ID32278025
Apelin, a specific endogenous ligand of the G protein-coupled receptor APJ, suppresses oxidative stress and apoptosis in vitro and in vivo. The current study explored whether Apelin protects against toxicity induced by the anticancer drug cisplatin in vitro, and the possible mechanisms that underlie this protective effect. The results showed ... More