Expression of CSF-1-receptor-related proteins in muscular stem cells.
AuthorsLeibovitch SA, Leibovitch MP, Borycki AG, Harel J,
JournalOncogene Res
PubMed ID2524026
We previously reported that consistent levels of c-fms-related transcripts are expressed during the growth of rat myogenic cells as well as in all neoplastic myoblasts. The present study extends this observation to mouse myogenic cells and demonstrates that a tyrosine-kinase-associated gp170, very similar or identical to the receptor for the ... More
A non-conserved miRNA regulates lysosomal function and impacts on a human lysosomal storage disorder.
AuthorsFrankel LB, Di Malta C, Wen J, Eskelinen EL, Ballabio A, Lund AH,
Journal
PubMed ID25524633
Sulfatases are key enzymatic regulators of sulfate homeostasis with several biological functions including degradation of glycosaminoglycans (GAGs) and other macromolecules in lysosomes. In a severe lysosomal storage disorder, multiple sulfatase deficiency (MSD), global sulfatase activity is deficient due to mutations in the sulfatase-modifying factor 1 (SUMF1) gene, encoding the essential ... More
A Genome-Wide Analysis Identifies a Notch-RBP-J?-IL-7Ra Axis That Controls IL-17-Producing ?d T Cell Homeostasis in Mice.
AuthorsNakamura M, Shibata K, Hatano S, Sato T, Ohkawa Y, Yamada H, Ikuta K, Yoshikai Y,
Journal
PubMed ID25429074
Notch signaling is an important regulator for the development and function of both aß and ?d T cells, whereas roles of Notch signaling in T cell maintenance remain unclear. We reported previously that the Notch-Hes1 pathway was involved in the intrathymic development of naturally occurring IL-17-producing (IL-17(+)) ?d T cells. ... More