Silencing of STRN4 suppresses the malignant characteristics of cancer cells.
AuthorsWong M, Hyodo T, Asano E, Funasaka K, Miyahara R, Hirooka Y, Goto H, Hamaguchi M, Senga T,
Journal
PubMed ID25250919
The striatin family of proteins, comprising STRN, STRN3 and STRN4, are multidomain-containing proteins that associate with additional proteins to form a large protein complex. We previously reported that STRN4 directly associated with protein kinases, such as MINK1, TNIK and MAP4K4, which are associated with tumor suppression or tumor progression. However, ... More
Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma.
AuthorsFu W, Asp P, Canter B, Dynlacht BD,
Journal
PubMed ID24927541
The primary cilium acts as a cellular antenna, transducing diverse signaling pathways, and recent evidence suggests that primary cilia are important in development and cancer. However, a role for cilia in normal muscle development and rhabdomyosarcoma (RMS) has not been explored. Here we implicate primary cilia in proliferation, hedgehog (Hh) ... More
Heterogeneous Responses to Mechanical Force of Prostate Cancer Cells Inducing Different Metastasis Patterns.
Authors
JournalAdv Sci (Weinh)
PubMed ID32775149
Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans.
Authors
JournalCell Res
PubMed ID35750757
The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding.
Authors
JournalCell Stem Cell
PubMed ID29033352
Unexpected contribution of fibroblasts to muscle lineage as a mechanism for limb muscle patterning.
Authors
JournalNat Commun
PubMed ID34158501
Stage-dependent cardiac regeneration in Xenopus is regulated by thyroid hormone availability.
Authors
JournalProc Natl Acad Sci U S A
PubMed ID30755533
Long noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly.
Authors
JournalNat Commun
PubMed ID32483152
Laminin regulates PDGFRβ(+) cell stemness and muscle development.
Authors
JournalNat Commun
PubMed ID27138650
Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing.
Authors
JournalNature
PubMed ID31645721
Peripheral re-localization of constitutive heterochromatin advances its replication timing and impairs maintenance of silencing marks.
Authors
JournalNucleic Acids Res
PubMed ID29750270
Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation.