Cytochalasin D reduces Ca2+ sensitivity and maximum tension via interactions with myofilaments in skinned rat cardiac myocytes.
AuthorsCalaghan SC, White E, Bedut S, Le Guennec JY
JournalJ Physiol
PubMed ID11101650
The F-actin disrupter cytochalasin D depresses cardiac contractility, an effect previously ascribed to the interaction of cytochalasin D with cytoskeletal actin. We have investigated the possibility that this negative inotropic effect is due to the interaction of cytochalasin D with sarcomeric actin of the thin filament.Confocal images of Triton X-100-skinned ... More