Suramin interacts with the calmodulin binding site on the ryanodine receptor, RYR1.
AuthorsPapineni RV, O'Connell KM, Zhang H, Dirksen RT, Hamilton SL
JournalJ Biol Chem
PubMed ID12364321
Apocalmodulin and Ca(2+) calmodulin bind to overlapping sites on the ryanodine receptor skeletal form, RYR1, but have opposite functional effects on channel activity. Suramin, a polysulfonated napthylurea, displaces both forms of calmodulin, leading to an inhibition of activity at low Ca(2+) and an enhancement of activity at high Ca(2+). Calmodulin ... More