A protein interaction map for cell polarity development.
AuthorsDrees BL, Sundin B, Brazeau E, Caviston JP, Chen GC, Guo W, Kozminski KG, Lau MW, Moskow JJ, Tong A, Schenkman LR, McKenzie A, Brennwald P, Longtine M, Bi E, Chan C, Novick P, Boone C, Pringle JR, Davis TN, Fields S, Drubin DG
JournalJ Cell Biol
PubMed ID11489916
'Many genes required for cell polarity development in budding yeast have been identified and arranged into a functional hierarchy. Core elements of the hierarchy are widely conserved, underlying cell polarity development in diverse eukaryotes. To enumerate more fully the protein-protein interactions that mediate cell polarity development, and to uncover novel ... More
Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells.
AuthorsBeronja S, Laprise P, Papoulas O, Pellikka M, Sisson J, Tepass U
JournalJ Cell Biol
PubMed ID15897260
Polarized exocytosis plays a major role in development and cell differentiation but the mechanisms that target exocytosis to specific membrane domains in animal cells are still poorly understood. We characterized Drosophila Sec6, a component of the exocyst complex that is believed to tether secretory vesicles to specific plasma membrane sites. ... More
The plane of first cleavage is not related to the distribution of sperm components in the mouse.
AuthorsDavies TJ, Gardner RL
JournalHum Reprod
PubMed ID12202427
BACKGROUND: Marking experiments using phytohaemagglutinin (PHA) and Concanavalin A (ConA) have suggested that the first cleavage plane is related to the point of sperm entry. Because of concerns about the specificity of lectin binding, the distribution of sperm components has been investigated directly. METHODS AND RESULTS: The sperm tail could ... More
Local Adaptation of Bitter Taste and Ecological Speciation in a Wild Mammal.