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引用和文献 (48)
Invitrogen™
羧基-DCFDA（5-(和-6)-羧基-2-',7'-二氯荧光素二乙酸），混合异构体
羧基-DCFDA 可被动扩散至细胞内，在乙酸酯基团被细胞内酯酶切割形成荧光基团 5-(和-6)-羧基-2',7'-二氯荧光素之前无色且不发荧光。鉴于 pKa 为 4.8，该染料可用作酸性 pH 值敏感探针。了解更多有关离子指示剂了解更多信息
| 货号 | 数量 |
|---|---|
| C369 | 100 mg |
货号 C369
价格（CNY)
5,113.00
Each
数量:
100 mg
价格（CNY)
5,113.00
Each
羧基-DCFDA 可被动扩散至细胞内，在乙酸酯基团被细胞内酯酶切割形成荧光基团 5-(和-6)-羧基-2',7'-二氯荧光素之前无色且不发荧光。鉴于 pKa 为 4.8，该染料可用作酸性 pH 值敏感探针。
了解更多有关离子指示剂（包括钙、钾、pH 值和膜电位指示剂）的信息›
了解更多有关离子指示剂（包括钙、钾、pH 值和膜电位指示剂）的信息›
仅供科研使用。不可用于诊断程序。
规格
检测方法荧光
染料类型pH 值指示剂
分子量529.29
数量100 mg
运输条件室温
适用于（应用）极性示踪剂, pH 值指示剂
适用于（设备）荧光显微镜
产品类型羧基-DCFDA
Unit SizeEach
内容与储存
在冰箱中（-5°C 至 -30°C）储存。
引用和文献 (48)
引用和文献
Abstract
Mitochondrial production of reactive oxygen species mediate dicumarol-induced cytotoxicity in cancer cells.
Journal:J Biol Chem
PubMed ID:17040906
'Dicumarol is a naturally occurring anticoagulant derived from coumarin that induces cytotoxicity and oxidative stress in human pancreatic cancer cells (Cullen, J. J., Hinkhouse, M. M., Grady, M., Gaut, A. W., Liu, J., Zhang, Y., Weydert, C. J. D., Domann, F. E., and Oberley, L. W. (2003) Cancer Res. 63,
Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow.
Journal:
PubMed ID:24385538
'How stem cells interact with the microenvironment to regulate their cell fates and metabolism is largely unknown. Here we demonstrated that the deletion of the cytoskeleton-modulating protein profilin 1 (pfn1) in hematopoietic stem cell (HSCs) led to bone marrow failure, loss of quiescence, and mobilization and apoptosis of HSCs in
KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells.
Journal:
PubMed ID:23674500
'Elevated oxidative stress is observed more frequently in cancer cells than in normal cells. It is therefore expected that additional exposure to a low level of reactive oxygen species (ROS) will push cancer cells toward death, whereas normal cells might maintain redox homeostasis through adaptive antioxidant responses. We previously showed
G-protein ligands inhibit in vitro reactions of vacuole inheritance.
Journal:J Cell Biol
PubMed ID:8027189
'During budding in Saccharomyces cerevisiae, maternal vacuole material is delivered into the growing daughter cell via tubular or vesicular structures. One of the late steps in vacuole inheritance is the fusion in the bud of vesicles derived from the maternal vacuole. This process has been reconstituted in vitro and requires
A trace amount of the human pro-apoptotic factor Bax induces bacterial death accompanied by damage of DNA.
Journal:J Biol Chem
PubMed ID:9556634
'An amount of human pro-apoptotic Bax as low as 0.01% of total protein was sufficient to cause cell death in Escherichia coli. The bacterial cell death was examined using a viable bacteria-specific fluorescence indicator system and loss of colony formation ability. Co-expression of anti-apoptotic Bcl-xL showed a modest inhibitory effect