Mertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cells.
Authors Feng Wei; Yasumura Douglas; Matthes Michael T; LaVail Matthew M; Vollrath Douglas;
JournalJ Biol Chem
PubMed ID11861639
The RCS rat is a widely studied model of recessively inherited retinal degeneration. The genetic defect, known as rdy (retinal dystrophy), results in failure of the retinal pigment epithelium (RPE) to phagocytize shed photoreceptor outer segment membranes. We previously used positional cloning and in vivo genetic complementation to demonstrate that ... More