In vivo imaging of tumors with protease-activated near-infrared fluorescent probes.
AuthorsWeissleder R, Tung CH, Mahmood U, Bogdanov A
JournalNat Biotechnol
PubMed ID10207887
'We have developed a method to image tumor-associated lysosomal protease activity in a xenograft mouse model in vivo using autoquenched near-infrared fluorescence (NIRF) probes. NIRF probes were bound to a long circulating graft copolymer consisting of poly-L-lysine and methoxypolyethylene glycol succinate. Following intravenous injection, the NIRF probe carrier accumulated in ... More