Invitrogen

CD34 Monoclonal Antibody (581), FITC

Name: CD34 Monoclonal Antibody (581), FITC
Brand: Invitrogen
SKU: CD34-581-01

7个已发表图片

16 篇参考文献

查看其他131个CD34抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

已发表图片 (7)

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CD34 Antibody (CD34-581-01) in Flow

Nature communications 2024 - Mutation-induced MDS HSCs' transcriptional reprogramming overcomes venetoclax-based therapy vulnerability. a Schematic of UPN#1's clinical course. After HMA therapy failure (cycle 0 [C0]), UPN#1 received 5-azacitidine (75 mg/m 2 for 5 days) and venetoclax (400 mg/m 2 for 14 days) every month. The patient had mCR at cycle 2 (C2); however, after the venetoclax dose was reduced to 100 mg/m 2 , the patient had ... View More

CD34 Antibody in Immunohistochemistry (IHC)

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产品信息

CD34-581-01

应用

建议稀释比

已发表文章

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

流式细胞分析 (Flow)

5 µL for 1x10^6 cells

查看15篇已发表文章 15篇已发表文章

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

581

抗原

Human CD34.

偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱

形式

Liquid

浓度

0.2 mg/mL

纯化类型

purified

保存液

PBS with 4mg/mL BSA

内含物

0.1% sodium azide

保存条件

4°C, store in dark

运输条件

Ambient (domestic); Wet ice (international)

AB_2536499

靶标信息

CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.

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