Role of NF-kappaB and PPAR-gamma in lung inflammation induced by monocyte-derived microparticles.
AuthorsNeri T, Armani C, Pegoli A, Cordazzo C, Carmazzi Y, Brunelleschi S, Bardelli C, Breschi MC, Paggiaro P, Celi A,
JournalEur Respir J
PubMed ID21148223
'Microparticles (MP) are phospholipid vesicles shed by cells upon activation or apoptosis. Monocyte-derived MP upregulate the synthesis of proinflammatory mediators by lung epithelial cells; the molecular bases of such activity are unknown. Peroxisome proliferator-activated receptors (PPAR) have been demonstrated to be involved in the modulation of nuclear factor (NF)-?B transcriptional ... More
Maggot secretions suppress pro-inflammatory responses of human monocytes through elevation of cyclic AMP.
Authorsvan der Plas MJ, Baldry M, van Dissel JT, Jukema GN, Nibbering PH,
JournalDiabetologia
PubMed ID19575178
'Maggots of the blowfly Lucilia sericata are used for the treatment of chronic wounds. As monocytes may contribute to the excessive inflammatory responses in such wounds, this study focussed on the effects of maggot secretions on the pro-inflammatory activities of these cells. Freshly isolated monocytes were incubated with a range ... More
Human cathelicidin antimicrobial protein 18 (hCAP18/LL-37) is increased in foetal membranes and myometrium after spontaneous labour and delivery.
AuthorsLim R, Barker G, Lappas M,
Journal
PubMed ID25435436
'Infection and/or inflammation are most commonly associated with preterm birth. Studies have shown that antimicrobial peptides can modulate the inflammatory response in non-gestational tissues; the human cathelicidin hCAP18 (and its active component LL-37) has such anti-microbial and immunomodulatory properties. The aim of this study was to determine the effect of ... More
Gamma interferon confers resistance to infection with Staphylococcus aureus in human vascular endothelial cells by cooperative proinflammatory and enhanced intrinsic antibacterial activities.
AuthorsBeekhuizen H, van de Gevel JS,
JournalInfect Immun
PubMed ID17893127
Vascular endothelium is an exposed target in systemic endovascular Staphylococcus aureus infections. We reported earlier that the proinflammatory and procoagulant activities of primary human umbilical vein endothelial cells (ECs) after binding and ingestion of S. aureus organisms provide the cells effective means for leukocyte-mediated bacterial elimination. Expanding on this, we ... More