Macrophage migration inhibitory factor elicits an angiogenic phenotype in human ectopic endometrial cells and triggers the production of major angiogenic factors via CD44, CD74, and MAPK signaling pathways.
AuthorsVeillat V, Carli C, Metz CN, Al-Abed Y, Naccache PH, Akoum A,
JournalJ Clin Endocrinol Metab
PubMed ID20829186
'An active angiogenesis is required for ectopic endometrial tissue growth. Our previous studies led to the identification of macrophage migration inhibitory factor (MIF), which is markedly elevated in active, vascularized, and early-stage endometriotic lesions, as a potent mitogenic factor for endothelial cells. Our objective was to study the mechanisms by ... More
Sesamin inhibits macrophage-induced vascular endothelial growth factor and matrix metalloproteinase-9 expression and proangiogenic activity in breast cancer cells.
AuthorsLee CC, Liu KJ, Wu YC, Lin SJ, Chang CC, Huang TS,
JournalInflammation
PubMed ID20617373
'Sesamin is a sesame component with antihypertensive and antioxidative activities and has recently aroused much interest in studying its potential anticancer application. Macrophage is one of the infiltrating inflammatory cells in solid tumor and may promote tumor progression via enhancement of tumor angiogenesis. In this study, we investigated whether sesamin ... More
Macrophage migration inhibitory factor up-regulates alpha(v)beta(3) integrin and vascular endothelial growth factor expression in endometrial adenocarcinoma cell line Ishikawa.
AuthorsBondza PK, Metz CN, Akoum A,
JournalJ Reprod Immunol
PubMed ID17854909
Human endometrium undergoes a series of dynamic physiological changes during the menstrual cycle of reproductive age women. Many factors, including hormones, cytokines, growth factors, matrix metalloproteinases and integrins, are essential for the success of embryonic implantation into endometrial tissue. Herein, we used a well-differentiated endometrial adenocarcinoma cell line, Ishikawa, to ... More
Effect of female sex hormones on Campylobacter rectus and human gingival fibroblasts.
AuthorsYokoyama M, Hinode D, Masuda K, Yoshioka M, Grenier D
JournalOral Microbiol Immunol
PubMed ID15943769
Recent studies have suggested a relationship between maternal Campylobacter rectus infections and preterm low birth weight. The purpose of this study was to investigate the effect of female sex hormones, estradiol and progesterone, on C. rectus and human gingival fibroblasts (HGF). The growth of C. rectus was significantly enhanced by ... More