Importance of ERK1/2 in upregulation of endothelin type B receptors in cerebral arteries.
AuthorsHenriksson M, Xu CB, Edvinsson L,
JournalBr J Pharmacol
PubMed ID15237095
'This study examines the importance of mitogen-activated protein kinases (MAPKs) in upregulation of endothelin type B (ETB) receptors. Rat middle cerebral arteries (MCAs) were incubated for 24 h with or without kinase inhibitors. Vessel segments were mounted in myographs and the contractile responses to endothelin-1 (ET-1; ETA and ETB receptor ... More
Differential tissue and ligand-dependent signaling of GPR109A receptor: Implications for anti-atherosclerotic therapeutic potential.
AuthorsGaidarov I, Chen X, Anthony T, Maciejewski-Lenoir D, Liaw C, Unett DJ,
Journal
PubMed ID23770183
Until recently, the anti-atherosclerotic effects of niacin were attributed primarily to its lipid modification properties mediated by adipocyte G-protein coupled receptor GPR109A, though recent studies have raised significant doubts about this mechanism. In fact, in rodents it has recently been demonstrated that niacin inhibits progression of atherosclerosis through actions on ... More