Decorin reverses the repressive effect of autocrine-produced TGF-beta on mouse macrophage activation.
AuthorsComalada M, Cardó M, Xaus J, Valledor AF, Lloberas J, Ventura F, Celada A,
JournalJ Immunol
PubMed ID12707320
'Several cytokines or growth factors induce macrophages to proliferate, become activated, differentiate, or die through apoptosis. Like the major macrophage activator IFN-gamma, the extracellular matrix protein decorin inhibits proliferation and protects macrophages from the induction of apoptosis. Decorin enhances the IFN-gamma-induced expression of the IAalpha and IAbeta MHC class II ... More
Role of interleukin-17A in cell-mediated protection against Staphylococcus aureus infection in mice immunized with the fibrinogen-binding domain of clumping factor A.
AuthorsNarita K, Hu DL, Mori F, Wakabayashi K, Iwakura Y, Nakane A,
JournalInfect Immun
PubMed ID20679443
Clumping factor A (ClfA) is a fibrinogen-binding cell wall-attached protein and an important virulence factor of Staphylococcus aureus. Previous studies reported that an immunization with the fibrinogen-binding domain of ClfA (ClfA(40-559)) protected animals against S. aureus infection. It was reported that some cytokines are involved in the pathogenesis of staphylococcal ... More