Immature rat myeloid dendritic cells generated in low-dose granulocyte macrophage-colony stimulating factor prolong donor-specific rat cardiac allograft survival.
AuthorsDePaz HA, Oluwole OO, Adeyeri AO, Witkowski P, Jin MX, Hardy MA, Oluwole SF,
JournalTransplantation
PubMed ID12605121
'Because the differential polarization of T cells in response to antigen presentation is dependent on the maturational state of dendritic cells (DCs), we hypothesized that the adoptive transfer of immature myeloid DCs (iMDCs) would prolong graft survival. To evaluate this hypothesis, we studied the effects of transfer of iMDCs and ... More
Methylenedioxymethamphetamine suppresses production of the proinflammatory cytokine tumor necrosis factor-alpha independent of a beta-adrenoceptor-mediated increase in interleukin-10.
AuthorsConnor TJ, Harkin A, Kelly JP,
JournalJ Pharmacol Exp Ther
PubMed ID15331655
Recent data suggest that 3,4-methylenedioxymethamphetamine (MDMA;
Strain-dependent inflammatory responsiveness of rat microglial cells.
AuthorsWei R, Lin CM,
JournalJ Neuroimmunol
PubMed ID19356804
The aim of this study is to test whether inflammatory responsiveness of rat microglial cells is strain-specific in primary microglia derived from neonatal LEW/N and F344/N rats. In contrast to F344/N microglia, LEW/N microglia constitutively and upon lipopolysaccharide challenge expressed higher levels of mRNA for the majority of inflammatory mediators ... More
Rat eosinophils stimulate the expansion of Cryptococcus neoformans-specific CD4(+) and CD8(+) T cells with a T-helper 1 profile.
AuthorsGarro AP, Chiapello LS, Baronetti JL, Masih DT,
JournalImmunology
PubMed ID21039463
Experimental Cryptococcus neoformans infection in rats has been shown to have similarities with human cryptococcosis, revealing a strong granulomatous response and a low susceptibility to dissemination. Moreover, it has been shown that eosinophils are components of the inflammatory response to C. neoformans infections. In this in vitro study, we demonstrated that ... More