Public T cell receptor beta-chains are not advantaged during positive selection.
AuthorsFurmanski AL, Ferreira C, Bartok I, Dimakou S, Rice J, Stevenson FK, Millrain MM, Simpson E, Dyson J
JournalJ Immunol
PubMed ID18178843
Studies of human and murine T cells have shown that public TCR beta-chain rearrangements can dominate the Ag-specific and naive repertoires of distinct individuals. We show that mouse T cells responding to the minor histocompatibility Ag HYDbSmcy share an invariant Vbeta8.2-Jbeta2.3 TCR gene rearrangement. The dominance of this rearrangement shows ... More
T cell receptor CDR3 loops influence alphabeta pairing.
AuthorsBartok I, Holland SJ, Kessels HW, Silk JD, Alkhinji M, Dyson J
JournalMol Immunol
PubMed ID20189651
T cell receptor transfer is an attractive strategy for the generation of antigen specific T cells to target infection and malignancy. Cross pairing of the transduced and endogenous TCR chains produces new and potentially auto-reactive specificities and dilutes the therapeutic TCR. This is further complicated as the efficiency of pairing ... More
Preservation of dendritic cell function during vesicular stomatitis virus infection reflects both intrinsic and acquired mechanisms of resistance to suppression of host gene expression by viral M protein.
AuthorsWestcott MM, Ahmed M, Smedberg JR, Rajani KR, Hiltbold EM, Lyles DS
Journal
PubMed ID23986580
Inhibition of host-directed gene expression by the matrix (M) protein of vesicular stomatitis virus (VSV) effectively blocks host antiviral responses, promotes virus replication, and disables the host cell. However, dendritic cells (DC) have the capacity to resist these effects and remain functional during VSV infection. Here, the mechanisms of DC ... More