Screening of nerve agent degradation products by MALDI-TOFMS.
AuthorsShu YR, Su AK, Liu JT, Lin CH,
JournalAnal Chem
PubMed ID16808484
'A novel method for the rapid screening of degradation products derived from nerve agents by matrix-assisted laser desorption ionization time-of-flight mass spectrometry is described. Five standard products were selected as model compounds, including isopropyl methylphosphonic acid (IMPA), pinacolyl methylphosphonic acid (PMPA), ethyl methylphosphonic acid (EMPA), isobutyl methylphosphonic acid (i-BuMPA), and ... More
N,N-dimethylsphingosine-coumarin: synthesis, chemical characterization, and biological evaluation.
AuthorsGhosh SC, Auzenne E, Farquhar D, Klostergaard J
JournalBioconjug Chem
PubMed ID17432826
'Coumarin derivatives of N,N-dimethylsphingosine (DMSP) were prepared and chemically characterized. They were apparently biologically equivalent to DMSP in terms of tumor cell cytotoxicity and were used to establish the rapid mitochondrial localization of this sphingolipid in tumor cells, followed closely by its marked reduction of mitochondrial membrane potential.' ... More
Crystal structure and photoluminescence of 7-(N,N'-diethylamino)-coumarin-3-carboxylic acid.
AuthorsZhang H, Yu T, Zhao Y, Fan D, Chen L, Qiu Y, Qian L, Zhang K, Yang C,
JournalSpectrochim Acta A Mol Biomol Spectrosc
PubMed ID17656149
'The structure of 7-(N,N''-diethylamino)-coumarin-3-carboxylic acid (DCCA) was verified by single crystal X-ray crystallography. The UV-vis absorption and fluorescence of DCCA were discussed. The compound exhibits strong blue emission under ultraviolet light excitation. The molecular structure of DCCA was optimized using density function theory (DFT) at B3LYP/6-31G level, showing that the ... More
Synthesis and microtubule binding of fluorescent paclitaxel derivatives.
AuthorsBaloglu E, Kingston DG, Patel P, Chatterjee SK, Bane SL
JournalBioorg Med Chem Lett
PubMed ID11527708
'The preparation of two new fluorescent derivatives of paclitaxel in which the fluorophore is bonded to paclitaxel at the C-10 position is reported. Both analogues, 10-deacetyl-10-(m-aminobenzoyl)paclitaxel (1, BTax) and 10-deacetyl-10-[7-(diethylamino) coumarin-3-carbonyl]paclitaxel (2, CTax) retain good activity as promoters of in vitro tubulin assembly. Microtubule binding enhances the emission intensity of ... More
A novel coumarin-type derivatizing reagent of alcohols: application in the CD exciton chirality method for microscale structural determination
AuthorsLo LC, Liao YC, Kuo CH, Chen CT,
JournalOrg Lett
PubMed ID10814409
[reaction: see text] Imidazolide 1 has been prepared from 7-diethylaminocoumarin-3-carboxylic acid (2) and 1,1'-carbonyldiimidazole. This novel fluorescent derivatization reagent can be used in CD exciton chirality method for microscale structural determinations of hydroxyl-containing compounds. It features a red-shifted chromophore and offers the advantages of fluorescence and high sensitivity. ... More