Spontaneous calcium oscillations control c-fos transcription via the serum response element in neuroendocrine cells.
AuthorsMaturana A, Van Haasteren G, Piuz I, Castelbou C, Demaurex N, Schlegel W
JournalJ Biol Chem
PubMed ID12121970
In excitable cells the localization of Ca2+ signals plays a central role in the cellular response, especially in the control of gene transcription. To study the effect of localized Ca2+ signals on the transcriptional activation of the c-fos oncogene, we stably expressed various c-fos beta-lactamase reporter constructs in pituitary AtT20 ... More
Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments.
AuthorsLiang F, Seyrantepe V, Landry K, Ahmad R, Ahmad A, Stamatos NM, Pshezhetsky AV
JournalJ Biol Chem
PubMed ID16835219
Human sialidase (neuraminidase) Neu1 catalyzes lysosomal catabolism of sialylated glycoconjugates. Here we show that during the differentiation of monocytes and the monocytic cell line, THP-1, into macrophages, the majority of Neu1 relocalizes from the lysosomes to the cell surface. In contrast to other cellular sialidases Neu2, Neu3, and Neu4, whose ... More
Hindered diffusion of high molecular weight compounds in brain extracellular microenvironment measured with integrative optical imaging.
AuthorsNicholson C, Tao L
JournalBiophys J
PubMed ID7508761
This paper describes the theory of an integrative optical imaging system and its application to the analysis of the diffusion of 3-, 10-, 40-, and 70-kDa fluorescent dextran molecules in agarose gel and brain extracellular microenvironment. The method uses a precisely defined source of fluorescent molecules pressure ejected from a ... More
Annexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases.
Authors
JournalJ Exp Med
PubMed ID28694388
A Method for Developing Novel 3D Cornea-on-a-Chip Using Primary Murine Corneal Epithelial and Endothelial Cells.
Authors
JournalFront Pharmacol
PubMed ID32410987
Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes.
Authors
JournalSci Rep
PubMed ID29895900
Type II Secretion Promotes Bacterial Growth within the Legionella-Containing Vacuole in Infected Amoebae.
Authors
JournalInfect Immun
PubMed ID31405960
Expression of endogenous retroviruses is negatively regulated by the pluripotency marker Rex1/Zfp42.
Authors
JournalNucleic Acids Res
PubMed ID22844087
Dietary Restriction Extends Lifespan through Metabolic Regulation of Innate Immunity.