'Late-stage malignant melanoma is a cancer that is refractory to current chemotherapeutic treatments. The average survival time for patients with such a diagnosis is 6 months. In general, the vast majority of anticancer drugs operate through induction of cell cycle arrest and cell death in either the DNA synthesis (S) ... More
Chlorophenols and chlorocatechols induce apoptosis in human lymphocytes (in vitro).
AuthorsMichalowicz J, Sicinska P,
JournalToxicol Lett
PubMed ID19766705
In this work the effect of 2,4,5-trichlorophenol (2,4,5-TCP), pentachlorophenol (PCP), 4,6-dichloroguaiacol (4,6-DCG), tetrachloroguaiacol (TeCG), 4,5-dichlorocatechol (4,5-DCC) and tetrachlorocatechol (TeCC) on the induction of apoptosis in human peripheral blood lymphocytes was examined. The analysis of the changes in mitochondrial transmembrane potential (DeltaPsi(m)) was performed using JC-9 fluorescent probe. It was noted ... More
Markers of apoptosis: methods for elucidating the mechanism of apoptotic cell death from the nervous system.
AuthorsSmyth PG, Berman SA,
JournalBiotechniques
PubMed ID11911667
Apoptosis is a highly conserved energy-requiring program for non-inflammatory cell death that is important in both normal physiology and disease. Numerous techniques have been used to study apoptosis. In the nervous system, apoptosis is necessary for normal development, but it also occurs in many acute and chronic pathologic conditions. This ... More
DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.
Authors
JournalDev Cell
PubMed ID28697336
A role for mitochondria in the establishment and maintenance of the maize root quiescent center.