Spatial nitric oxide imaging using 1,2-diaminoanthraquinone to investigate the involvement of nitric oxide in long-term potentiation in rat brain slices.
Authorsvon Bohlen und Halbach O, Albrecht D, Heinemann U, Schuchmann S
JournalNeuroimage
PubMed ID11848706
'Long-term potentiation (LTP), a model of activity-dependent synaptic plasticity, involves the persistent enhancement of excitatory neurotransmission. Several recent studies have suggested a critical role for nitric oxide (NO) production in hippocampal LTP. However, increase in NO production in living tissue has not yet been directly demonstrated. We used 1,2-diaminoanthraquinone (DAQ) ... More
NO production during neuronal cell death can be directly assessed by a chemical reaction in vivo.
AuthorsHeiduschka P, Thanos S
JournalNeuroreport
PubMed ID9926846
The role of nitric oxide (NO) as a putative mediator of neuronal death can be understood best if NO is detected directly. For this purpose, we developed a new sensitive method that for the first time directly captures released NO during neurodegeneration in vivo and at the cellular site of ... More
Nitric oxide modulates low-Mg2+-induced epileptiform activity in rat hippocampal-entorhinal cortex slices.
AuthorsSchuchmann S, Albrecht D, Heinemann U, von Bohlen und Halbach O
JournalNeurobiol Dis
PubMed ID12460549
The production of nitric oxide (NO) during low-Mg2+-induced epileptiform activity in rat hippocampal-entorhinal cortex slices was investigated by real-time monitoring using 1,2-diaminoanthraquinone (DAQ). NO reacts with the aromatic amino groups of DAQ at neutral pH and in the presence of oxygen to form the fluorescence product 1H-anthra-[1,2d]-[1,2,3]triazole-6,11-dione (ATD). The DAQ-induced ... More
Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation.
AuthorsMartin LJ, Chen K, Liu Z
JournalJ Neurosci
PubMed ID16000635
The mechanisms of injury- and disease-related degeneration of motor neurons (MNs) need clarification. Unilateral avulsion of the sciatic nerve in the mouse induces apoptosis of spinal MNs that is p53 and Bax dependent. We tested the hypothesis that MN apoptosis is Fas death receptor dependent and triggered by nitric oxide ... More