ε-Dabcyl-α-FMOC-L-Lysine, ε-(4-((4-(Dimethylamino)phenyl)azo)benzoyl)-α-9-Fluorenylmethoxycarbonyl-L-Lysine

ε-Dabcyl-α-FMOC-L-Lysine, ε-(4-((4-(Dimethylamino)phenyl)azo)benzoyl)-α-9-Fluorenylmethoxycarbonyl-L-Lysine - Citations

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Abstract

Design of sensitive fluorogenic substrates for human cathepsin D.

AuthorsGulnik SV, Suvorov LI, Majer P, Collins J, Kane BP, Johnson DG, Erickson JW

JournalFEBS Lett

PubMed ID9280316

Cathepsin D is a lysosomal aspartic proteinase that has been implicated in several pathological processes such as breast cancer and Alzheimer's disease. We designed and synthesized a number of quenched fluorogenic substrates with P2 variations in the series AcEE(EDANS)KPIXFFRLGK(DABCYL)E-NH2, where X=cysteine, methylcysteine, ethylcysteine, tert-butylcysteine, carboxymethylcysteine, methionine, valine or isoleucine. Most ... More