The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance.
AuthorsHayward R, Saliba KJ, Kirk K
JournalJ Cell Sci
PubMed ID16492710
'Chloroquine resistance in the human malaria parasite, Plasmodium falciparum, arises from decreased accumulation of the drug in the ;digestive vacuole'' of the parasite, an acidic compartment in which chloroquine exerts its primary toxic effect. It has been proposed that changes in the pH of the digestive vacuole might underlie the ... More
Imaging calcium dynamics in the nervous system by means of ballistic delivery of indicators.
AuthorsKettunen P, Demas J, Lohmann C, Kasthuri N, Gong Y, Wong RO, Gan WB
JournalJ Neurosci Methods
PubMed ID12234633
The use of fluorescence-based calcium indicators has, over the years, unraveled important calcium-dependent mechanisms underlying neuronal function and development. However, difficulties associated with the loading of calcium indicators have limited their widespread use, particularly for the study of neuronal processing in the adult nervous system. Here, we show that in ... More