Fluorescence lifetime-resolved pH imaging of living cells.
AuthorsLin HJ, Herman P, Lakowicz JR
JournalCytometry A
PubMed ID12655651
BACKGROUND: The regulation and maintenance of intracellular pH are critical to diverse metabolic functions of the living cells. Fluorescence time-resolved techniques and instrumentations have advanced rapidly and enabled the imaging of intracellular pH based on the fluorescence lifetimes. METHODS: The frequency-domain fluorescence lifetime imaging microscopy (FLIM) and fluorophores displaying appropriate ... More
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PubMed ID34556786
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PubMed ID28841136
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