Alteration in lung particle translocation, macrophage function, and microfilament arrangement in monocrotaline-treated rats.
AuthorsMadl AK, Wilson DW, Segall HJ, Pinkerton KE
JournalToxicol Appl Pharmacol
PubMed ID9875297
'Individuals with preexisting cardiopulmonary disease are thought to be more susceptible to acute episodes of particulate pollution resulting in increased morbidity and mortality. Our study was designed to evaluate particle fate and macrophage function in an animal model of monocrotaline (MCT)-induced pulmonary hypertension. Two weeks following a single MCT injection, ... More
Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture.
AuthorsLangevin HM, Churchill DL, Cipolla MJ
JournalFASEB J
PubMed ID11641255
The mechanism of action of acupuncture remains largely unknown. The reaction to acupuncture needling known as 'de qi', widely viewed as essential to the therapeutic effect of acupuncture, may be a key to understanding its mechanism of action. De qi includes a characteristic needling sensation, perceived by the patient, and ... More
SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development.
AuthorsBear JE, Rawls JF, Saxe CL
JournalJ Cell Biol
PubMed ID9732292
G protein-coupled receptors trigger the reorganization of the actin cytoskeleton in many cell types, but the steps in this signal transduction cascade are poorly understood. During Dictyostelium development, extracellular cAMP functions as a chemoattractant and morphogenetic signal that is transduced via a family of G protein-coupled receptors, the cARs. In ... More