Early cellular events couple covalent binding of reactive metabolites to cell killing by nephrotoxic cysteine conjugates.
Authors:Chen Q, Jones TW, Stevens JL
Journal:J Cell Physiol
PubMed ID:7525611
'Addition of the nephrotoxic cysteine conjugate, S-(1,2-dichlorovinyl)-L-cysteine (DCVC), to the LLC-PK1 line of renal epithelial cells leads to covalent binding of reactive intermediates followed by thiol depletion, lipid peroxidation, and cell death (Chen et al., 1990, J. Biol. Chem., 265:21603-21611). The present study was designed to determine if increased intracellular ... More