Identification and characterization of murine SCARA5, a novel class A scavenger receptor that is expressed by populations of epithelial cells.
AuthorsJiang Y, Oliver P, Davies KE, Platt N
JournalJ Biol Chem
PubMed ID16407294
'Epithelia are positioned at a critical interface to prevent invasion by microorganisms from the environment. Pattern recognition receptors are important components of innate immunity because of their ability to interact with specific microbe-associated structures and initiate immune responses. Several distinct groups of receptors have been recognized. One of these, the ... More
Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila.
AuthorsFranc NC, Heitzler P, Ezekowitz RA, White K
JournalScience
PubMed ID10373118
Macrophages in the Drosophila embryo are responsible for the phagocytosis of apoptotic cells and are competent to engulf bacteria. Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages. Genetic evidence showed that crq was essential for efficient phagocytosis of apoptotic corpses but was not required for the engulfment ... More