Epoxide hydrolases: biochemistry and molecular biology.
AuthorsFretland AJ, Omiecinski CJ
JournalChem Biol Interact
PubMed ID11154734
'Epoxides are organic three-membered oxygen compounds that arise from oxidative metabolism of endogenous, as well as xenobiotic compounds via chemical and enzymatic oxidation processes, including the cytochrome P450 monooxygenase system. The resultant epoxides are typically unstable in aqueous environments and chemically reactive. In the case of xenobiotics and certain endogenous ... More
Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles.
AuthorsMorisseau C, Hammock BD
JournalAnnu Rev Pharmacol Toxicol
PubMed ID15822179
'Organisms are exposed to epoxide-containing compounds from both exogenous and endogenous sources. In mammals, the hydration of these compounds by various epoxide hydrolases (EHs) can not only regulate their genotoxicity but also, for lipid-derived epoxides, their endogenous roles as chemical mediators. Recent findings suggest that the EHs as a family ... More