Design of allele-specific protein methyltransferase inhibitors.
Authors Lin Q; Jiang F; Schultz P G; Gray N S;
JournalJ Am Chem Soc
PubMed ID11716715
Protein arginine methyltransferases, which catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to arginine side chains in target proteins, regulate transcription, RNA processing, and receptor-mediated signaling. To specifically address the functional role of the individual members of this family, we took a ... More
Cathepsin S expression is up-regulated following balloon angioplasty in the hypercholesterolemic rabbit.
AuthorsBurns-Kurtis CL, Olzinski AR, Needle S, Fox JH, Capper EA, Kelly FM, McQueney MS, Romanic AM,
JournalCardiovasc Res
PubMed ID15158154
OBJECTIVE: Neointimal development following balloon angioplasty involves many factors including smooth muscle cell (SMC) migration and proliferation and extracellular matrix (ECM) remodeling. Further, in hypercholesterolemic (HC) conditions, there is an influx of macrophage foam cells (FCs) into the restenotic lesion, which also involves degradation of the basement membrane and surrounding ... More